www.englishmed.com - Home

Start > Resource centre > Find the articles > Gene therapy may offer release from sterile isolation for patients lacking immune systems Part 3

We have mixed up all the articles (a, an, the) in the text below, try and find the correct place for each one..

Gene therapy may offer release from sterile isolation for patients lacking immune systems Part 3 (Teacher: Michael)

The children are Sheila, 18-month Palestinian, and girl from Colombia. Bordignon and his colleagues removed some of bone marrow from pelvises of two patients in study. Next, they isolated blood stem cells, which have potential to develop into body's various red and white blood cells. When researchers exposed stem cells to engineered virus carrying healthy version of ADA gene, virus inserted gene into stem's cell's genome.

Before injecting engineered stem cells into patients, science authors performed additional step, which they believed would make their efforts more successful than previous efforts to treat SCID with gene therapy. Until now, Bordignon says, these efforts have not established enough healthy stem cells in body for results to last. This time around, process called "non-myeloblative conditioning" may make difference, according to researchers.

"Non-myeloblative condition means you don't really wipe out bone marrow, you just give one of drugs used for transplant, at much lower dose to make space for engineered marrow to size, expand and grow better," Bordignon explained.

Within weeks of being injected into patients, engineered stem cells migrated to bone marrow, and began spawning key types of immune cells, such as B cells, T cells and NK cells. Within months, antibodies appeared and patients responded normally to small amounts of certain pathogens, such as tetanus vaccine. One year later, one of patients no longer had respiratory infections, chronic diarrhoea or scabies that were common before therapy.

Read the article

VLC ClozeMaker JavaScript Wizard.
All Rights Reserved.